Kariminejad-Najmabadi Pathology & Genetics Center performs hundreds of diagnostic tests annually onaffected individuals, in addition toprenatal diagnosis, and carrier detection on patients with genetic diseases.The Center is staffed by well qualified, experiencedpersonnelworking in a modern lab environmentusing state-of-the-artequipment.

Overthe past 38 years, the Center has performed a huge number of prenatal and postnatal diagnoses for genetic diseases and abnormalities.This isthanks to its commitment and transparency in providingcomprehensive services according to international best practices and backed byits pioneeringsole founders,its managers and staff.From referral satisfaction and counseling services, it is the most trusted organization for individuals and institutions and is a shining example among its diagnostic counterparts in the country and the region.

Kariminejad-Najmabadi Pathology &Genetics Center is a pioneering organization that serves as a model for establishing and presenting new diagnostic services.It hasbeen our priority to take care patient satisfactionwho are affectedby genetic disorders and abnormalities.The high rate of successful test results and highly qualitative and quantitative results in comparison with other international standard services, have made Kariminejad-Najmabadi Pathology & Genetics Center a leading-edge genetics service.

Kariminejad-Najmabadi Pathology & Genetics Center is staffedby over 100 highly educated specialists and technicians, many of whom are graduates from eminent national and international universities, and who are familiar with leading-edge research in their field.The Center has access to the world’s latest technology, and makes every attempt to stay current with all recent developments available to it throughtheCenter, and when not possible, via collaboration and close scientific links with various prestigious scientists in referral centers worldwide.Itsgoal and principal aim is the achievementof rapid turnaround and high accuracy ingenetics results.

Kariminejad-Najmabadi Pathology & Genetics Center, as a multi-disciplinary laboratory, provides counseling and diagnostic genetics services.Our portfolio is continuously expanding by setting up tests for new genes and by implementing novel methods and approaches. All outpatient and inpatient medical laboratory specimen collections, for patients of all ages, can be performed at our laboratory. A team of expert clinical laboratory geneticists performs the interpretation of all test results and our laboratory carries outall tests under strict quality requirements. All patients are provided with pre- and post-test genetic counseling describing the tests to families and their impact on those families.

Diagnostic services are offered for over 450 genetic disorders and more than 900 genes. All of the services include a full diagnostic interpretation of clinically relevant variants. Although it is difficult to separate the specialized activities of the different divisions in this Center, to familiarize both specialists and families, details of our divisions and their related diagnostic services are now briefly described.

Counseling and Clinical Genetics Division

• Premarital, and consanguineous marriage genetic counseling,
• Genetic counseling before and during pregnancy,
• Genetic counseling for hereditary disorders, intellectual disabilities, connective tissue disorders, skeletal dysplasia, hereditary skin disease, …
• Genetic counseling for infertility, miscarriage, stillbirth, and ambiguous genitalia,
• Genetic counseling for familial cancers
• Genetic counseling for metabolic disorders in proband or family for prenatal diagnosis in future pregnancies,
• Genetic counseling for molecular investigation of all the known genetic disorders (if necessary,via collaboration with various referral centers worldwide).

Pathology and Cytology Division

• Clinical pathology,
• Anatomical pathology,
• Postmortem exam,
• Cytology,
• Molecular fluorescence in situ hybridization (FISH): tissue and cell.

Cytogenetic Division

• Prenatal diagnosis: Common banding techniques in blood samples, amniotic fluid, and chorionic villus samples,
• Postnatal diagnosis: Banding techniques and high resolution banding in peripheral blood and tissue samples,
• Malignancy: Identification of the type of leukemia and lymphoma, selecting the most effective treatment, and controlling the response to cancer therapy using bone marrow.

Molecular Cytogenetic Division

• Detection of deletions, microdeletions, translocations, inversions, and numerical chromosomal abnormalities using the banding technique and FISH,
• Array Comparative Genomic Hybridization (aCGH) and Preimplantation Genetic Screening (PGS),
• BACligoarrayComparative Genomic Hybridization (oaCGH).

Molecular Division

• Single gene diagnostics by Sanger sequencing,
• Multiple gene diagnostics by targeted next generation sequencing,
• Exome sequencing diagnostics for intellectual disabilities, hearing loss, neuromuscular disorders, cancers, metabolic disorders,  hematological disorders, and …,
• Mutation detection (carrier testing),
• Preimplantation Genetic Diagnosis (PGD),
• Non-invasive Prenatal Testing (NIPT),
• Cancer mutation detection for predictive reasons (response to cancer therapy),
• Quantitative and qualitative molecular assessment of leukemias,
• Prenatal screening for aneuploidies by Quantitative Fluorescence Polymerase Chain Reaction (QF-PCR).

Scientific and Diagnostic Collaborations with Internal and International  Centers around the world

• Metabolic Disorders

Collaboration with Erasmus University, Rotterdam, The Netherlands: This scientific collaboration started in 1987 in a  of free charge research framework withtheMetabolic Department of Erasmus University, and resulted in 826 metabolic investigations for our patients as well as 222 prenatal diagnoses. This successful collaboration is still ongoing.

• Bone Dysplasia Disorders

Our centerenterhas consultedrenownedradiologists in the International Skeletal Dysplasia Registry (ISDR) for detection of skeletal dysplasia disorders by sending them the X-rays as well as the comprehensiveclinical descriptions of patients. Up to now, 113 clinical descriptions and X-rays of our patients have been sent to ISDR and we have benefited from their clinical expertise.  We have been able to help families reach clinical diagnoses in cases of very rare skeletal dysplasiasand confirm the diagnosis with molecular testing.

• Hereditary Disorders of Connective Tissue

• Our center is very interested in connective tissue disorders and we have very good experience with cutis laxa syndromes, Ehlers Danlos, Osteogenesis Imperfecta, and Marfan Syndrome. 

•  focusing on epidermolysis bullosa, ichthyosis and other skin disorders.